A major predator species in the Great Plains would actually do pretty well, given that after the last ice age, the majority of the bison's predators went extinct as well as the competitors of the bison, like horses and prehistoric giant bison. As long as it can survive harsh winters and be able to locate water during droughts, a large predator would do pretty well.
Although if the bison population were to collapse, say by a mixture of drought, introduction of millions of horses, massive demand for their pelts, and deliberate overhunting, then I can't imagine this large predator would survive with the majority of its prey extinct. Ranchers would demand this large predator be eliminated and likely do a very good job at it. It would certainly make for an interesting addition to Westerns. Imagine cowboys shooting lions from horseback.
Although if the bison population were to collapse, say by a mixture of drought, introduction of millions of horses, massive demand for their pelts, and deliberate overhunting, then I can't imagine this large predator would survive with the majority of its prey extinct. Ranchers would demand this large predator be eliminated and likely do a very good job at it. It would certainly make for an interesting addition to Westerns. Imagine cowboys shooting lions from horseback.